Mechanochemical synthesis of thioureas, ureas and guanidines

• Vjekoslav Štrukil

Beilstein J. Org. Chem. 2017, 13, 1828–1849, doi:10.3762/bjoc.13.178

• in the solid-state before having been exposed to microwave irradiation for 1.5–4.5 minutes. In their paper, the authors state: "Aryl isothiocyanate (1 mmol) and aromatic primary amine (1 mmol) were mixed thoroughly in an agate mortar" [33]. Considering the established reactivity pattern of electron

Derivatives of the triaminoguanidinium ion, 3. Multiple N-functionalization of the triaminoguanidinium ion with isocyanates and isothiocyanates

• Jan Szabo,
• Kerstin Karger,
• Nicolas Bucher and
• Gerhard Maas

Beilstein J. Org. Chem. 2014, 10, 2255–2262, doi:10.3762/bjoc.10.234

• 7a and 8 show interesting solid-state structures with intra- and intermolecular hydrogen bonds. Keywords: aryl isocyanate; aryl isothiocyanate; carbamoylation; sulfonyl isocyanate; triaminoguanidinium salt; 1H-1,2,4-triazole-5(4H)-thione; Introduction The 1,2,3-triaminoguanidinium ion, [C(NHNH2)3

• formed in a second thiocarbamoylation step. Benzylhydrazine, which is liberated in the course of the cyclization step, is transformed into byproduct 11 by thiocarbamoylation of both nitrogen atoms with the aryl isothiocyanate. The formation of triazole 12 is related to the reaction of TAG-NO3 with phenyl